The hyperparameters in Gaussian process regression (GPR) model with a specified kernel are often estimated from the data via the maximum marginal likelihood. Due to the non-convexity of marginal likelihood with respect to the hyperparameters, the optimisation may not converge to the global maxima. A common approach to tackle this issue is to use multiple starting points randomly selected from a specific prior distribution. As a result the choice of prior distribution may play a vital role in the predictability of this approach. However, there exists little research in the literature to study the impact of the prior distributions on the hyperparameter estimation and the performance of GPR. In this paper, we provide the first empirical study on this problem using simulated and real data experiments. We consider different types of priors for the initial values of hyperparameters for some commonly used kernels and investigate the influence of the priors on the predictability of GPR models. The results reveal that, once a kernel is chosen, different priors for the initial hyperparameters have no significant impact on the performance of GPR prediction, despite that the estimates of the hyperparameters are very different to the true values in some cases.